Optomicrofluidic platforms for rapid and sensitive detection of biomarkers in medical diagnostics

Optomicrofluidic sensing platforms, which integrate optical detection methods with microfluidic technology, have shown significant promise in laboratory settings. These platforms utilize functionalized optical transducers, such as plasmonic nanostructures or periodic gratings, for rapid and accurate detection of specific biological molecules. Here, we report on the design and application of optomicrofluidic platforms based on localized surface plasmon resonance (LSPR) with gold nanospikes and short-length long-period gratings (SL-LPG) in detecting and quantifying biomarkers like anti-SARS-CoV-2 antibodies and prostate cancer (PCa) biomarkers in real samples.